![Association between genetic variants of TLR2 , TLR4 , TLR9 and schizophrenia [Association entre les variants génétiques des TLR2 , TLR4 , TLR9 et la schizophrénie]](https://bibliotheque.cpa01.fr/img_cache/pmb_cpa_record_115172.webp)
| Titre : | Association between genetic variants of TLR2 , TLR4 , TLR9 and schizophrenia [Association entre les variants génétiques des TLR2 , TLR4 , TLR9 et la schizophrénie] |
| Auteurs : | AYARI F, Aut. ; BEN CHAABEN A, Aut. ; ABAZA H, Aut. ; MIHOUB O, Aut. ; OUNI N, Aut. ; BOUKOUACI WAHID, Aut. ; KHARRAT MAHER, Aut. ; LEBOYER MARION, Aut. ; GUEMIRA F, Aut. ; TAMOUZA R, Aut. ; MANKAI AMANI, Aut. |
| Type de document : | Article |
| Dans : | ENCEPHALE (2 vol 50, 2024) |
| Article en page(s) : | 178-184 |
| Note générale : | 47 réf. bibliogr./Fig./Tabl./ascodo302 |
| Descripteurs |
[LISTES] TUNISIE [SANTEPSY] ETIOLOGIE [SANTEPSY] GENETIQUE [SANTEPSY] GENOTYPE [SANTEPSY] LIMITE [SANTEPSY] SCHIZOPHRENIE |
| Résumé : | Background and study aim : Schizophrenia (SZ) is a multifactorial disorder involving complex interactions between genetic and environmental factors, where immune dysfunction plays a key etiopathogenic role. In order to explore the control of innate immune responses in SZ, we aimed to investigate the potential association between twelve TLR2, TLR4 and TLR9 variants (TLR2: rs4696480T > A, rs3804099T > C, rs3804100T > C; TLR4: rs1927914G > A, rs10759932T > C, rs4986790A > G, rs4986791T > C, rs11536889G > C, rs11536891T > C; TLR9: rs187084A > G, rs352139T > C and rs352140C > T) and SZ susceptibility in a Tunisian population. Patients and methods : This study included 150 patients and 201 healthy controls with no history of psychiatric illness. Genotyping was done using a TaqMan SNP genotyping assay. We also assessed a haplotype analysis for TLR2, TLR4 and TLR9 variants with SZ using Haploview 4.2 Software. Results : We found that the AA genotype of the TLR2 rs4696480T > A variant was significantly associated with an increased risk of SZ (46% vs. 31%, P = 4.7 × 10?3, OR = 1.87 and 95% CI [1.18–2.97]). The frequency of the TA genotype was significantly higher in the control group than in SZ patients (27% vs. 43%, P = 2.1 × 10?3) and may be associated with protection against SZ (OR = 0.49 and 95% CI [0.30–0.80]). Whereas, the TLR9 rs187084-GG genotype was higher in the control group compared to patients (16% vs. 5%, P = 1.6 × 10?3) and would present protection against SZ (OR = 0.28, CI = [0.10–0.68]). The ACT haplotype of the TLR2 and the ACC haplotype of the TLR9 gene were identified as a risk haplotypes for SZ (P = 0.04, OR = 9.30, 95% CI = [1.11–77.71]; P = 3 × 10?4, OR = 6.05, 95% CI = [2.29–15.98], respectively). Conclusion : The results indicate that TLR2 and TLR9 genetic diversity may play a role in genetic vulnerability to SZ. However, including more patients and evaluation of TLR2 and TLR9 expression are recommended. [Résumé d'auteur] |
| En ligne : | https://www.em-premium.com/article/1656798 |
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